Hypersecretion
Since the secretory rates are already close to their maximum, further stimulation with histamine generally produces very little response. Marks et al. have suggested that a ratio of basal acid output to histamine-stimulated output of greater than 60 percent is virtually diagnostic of the Zollinger-Ellison syndrome, but exceptions are common than generally recognized. The extreme gastric hypersecretion is associated with distressing watery diarrhea in about a third of the reported cases. ICD10 Certification.makes you spend more time with patients and increase the quality of the care.